ABSTRACT
This study examined the nephrotic effect
of Buchholzia coriacea formulated
diet in sucrose-fed pregnant rats and their offspring. Buchholzia coriacea (B. coriacea) (family, capparidaceae) is a perennial plant commonly known as wonderful
kola.
Seeds were obtained from ogbete main market, Enugu state, identified, dried and
grounded using a miller machine. 10% of the seed powder was used to formulate
their diet. Thirty (240) adult female and six (6) adult male albino rats
(180-250 g) were used in this study. High sucrose (20%) weregivenvia drinking
water to animals before, during and after pregnancy. Group A; Control normal
was administered distilled water, Group B received sucrose + 10% Buchholzia Coriacea formulated diet (BCFD),
Group C; untreated rats were administered sucrose and distilled water while
Group D received 10% Buchholzia Coriacea
formulated diet (BCFD) only. All animals were sacrificed following overnight
fastby anaesthetic dose of diethyl ether and cervical dislocation. Blood
samples were obtained through cardiac puncture for the analysis
of biochemical parameters. Results were represented as mean ± standard error of
mean. SUC (20%) (untreated) significantly elevated urea levels (p<0.05);
Creatinine (p<0.05) and LPO of the Kidney (p<0.05); (when compared with normal control group. However,
following treatment with BCFD, the Urea, Creatinine and MDA level in treated
rats were significantly reduced (p<0.05) when compared with the untreated
group. Interestingly, all offspring showed reduced Urea level, Creatinine level
and low MDA level in the Kidney except for the negative control whose offspring
showed significant increase (p<0.05) in the parameters when compared with
the normal group. In conclusion, this research suggests that buchholzia coriacea seeds has protective
effect on the damage induced by high sucrose diet on the kidney of pregnant
rats as well as their offsprings.
CHAPTER ONE
INTRODUCTION
1.1 Background of Study
Malnutrition
during pregnancy creates health risks for both the pregnant woman her
developing fetus. Not eating enough or eating too much can create health risks,
for both the pregnant woman and her developing fetus over nutrition during
pregnancy is common in developed countries.
Many
woman experience increased appetite during pregnancy. This occurs partly
because their hormonal balance is altered, but also because the growing fetus
removes food by products from their blood. It is also possible for woman to
consume too much during pregnancy and gain excessive weight.
Woman
who over consume during pregnancy increase their risk of obesity i.e. woman who
gain excessive weight during pregnancy often fail to lose weight after
childbirth and risk becoming overweight or obese, pre-exclaims psiai.e a
condition which occurs in late pregnancy and s characterized by high levels of
protein in the urine, hypertension and excessive fluid in tissues, gestational
diabetes. Macros Omnia (fetus over- growth) can occur because a pregnant woman
over consumers for example, excessive transfer of glucose and other nutrients
can occur in pregnant woman with diabetes. As the nutrition a fetus receives in
the womb pregnancies the metabolic system to function later in life over
nourished fetuses have an increased risk of obesity and associated metabolic
condition 5 such as type 2 diabetes later in life.
There
is also evidence of an increased risk of the infant experiencing polycythemias
the abnormally high red blood cell concentration seizures.
Eating
too much sugar during pregnancy could affect your child’s intelligence and
memory (American Journal of preventative medicine) consuming too much sugar
acids gain weight. This added to me naturally increasing pregnancy weight, can
lead to obesity, which can complicate the delivery. It also leads to containing
sugars can lead to the fatty liver syndrome. It can also affect the fetal
metabolism in life ( B.Sc Pharm MD and Erick Yoshida, MD MHSc FRCPC). It
increases the risk of preeclampsia, high sugar, high sugar intake influences
the risk of preeclampsia in pregnant women (EUR JCLIN NUTR. 2012) Aug. 66(8)
920-5 doi:10.103/ESCN 2012.61. EPUB 2012 Jun 20).
Wonderful
kola also known as (buchholzia seeds is quickly gaining popularity as it seems
to be a cure to almost all ailments. It’s look stands out from the normal kola
as it look like a root and not a fruit like the others.
This
plant grows in different states including Congo, Nigeria, and others. This
plant is known as evergreen, and its seeds are widely used in medicine.
However, more frequently it is used in herbal medicine rather than traditional.
1.2 Statement
of the problem
The
consumption of added sugars (sucrose) over the last 200 years has increased
exponentially and parallels the creased prevalence of chronic kidney disease.
Data for animals and humans suggest that the consumption of added sugars leads
to kidney damage and related metabolic derangements that increase
cardiovascular risk. Importantly, the consumption of added sugars has been
sound to induce insulin resistance and increase uric acid in humans, both of
which increase the conversion of glucose and fructose via the payola pathway.
The payola pathway has recently been implicated in the contrition and
progression of kidney damage.
To
mitigate this serious complications and a negative outcome of kidney disease,
the plant Buccholzia coriacea can be used as therapeutic option readily
available to cure the damage caused by high sucrose.
1.3 Objective
of the Study
The
general of the, this study was to evaluate the biochemical/metabolic effect of
sucrose on a sucrose fed pregnant rat and their offspring’s. The specific objectives
are to
1. to
induce the rats with sucrose
2. Carryout
biochemical assays including, serum urea nitrogen and lipid per oxidation, serum
creatinine.
1.4 Significant
of the study
This
study will increase our understanding on the renal effect of buccholzia
coriacea on the kidney function indices of a sucrose fed pregnant rats. It is
hope that constituent compounds present in buchholziacoriacea would aid further
scientific investigation while contributing to the drug discovery and
development.
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Item Type: Project Material | Attribute: 50 pages | Chapters: 1-5
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