ABSTRACT
Several plants have
been used in the treatment of various disorders without scientific basis. The
present study examine the pancreatic effect of Buchholzia coriacea formulated diet in sucrose-fed pregnant rats
and their offspring. Buchholzia coriacea
seeds were obtained from Ogbete main market, Enugu state, identified, dried and
grounded using a miller machine. 10% of the seed powder was used to formulate
their diet. Thirty (240) adult female and six (6) adult male albino rats
(180-250 g) were used in this study. High sucrose (20%) were given via drinking
water to animals before, during and after pregnancy. Group A; Control normal
was administered distilled water, group B received sucrose + 10% Buchholzia Coriacea formulated diet
(BCFD), Group C; untreated rats were administered sucrose and distilled water
while Group D received 10% Buchhoiza
Coriacea formulated diet (BCFD) only. All animals were sacrificed following
overnight fast by anaesthetic does of diethylether and cervical dislocation.
Blood samples were obtained through cardiac puncture error of mean. SUC (20%)
(untreated) significantly elevated blood
glucose levels (P<0.05); Leptin (P<0.05) and LPO of the pancreas
(P<0.05); (when compared with normal control group. However, following
treatment with BCFD, the blood glucose level in treated rats were significantly
reduced when compared with the untreated group. Interestingly, all offspring
showed reduced blood glucose level, leptin level and low MDA level in the
pancreas except for the negative control whose offspring showed significant
increase (P<0.05) in the paramenters when compared with the normal group. In
conclusion, this research suggests that Buchholzia
Coriacea seeds has protective effect on the damage induced by high sucrose
diet on the pancreas of pregnant rats as well as their offsprings.
CHAPTER ONE
1.0 INTRODUCTION
1.1 BACKGROUND
OF THE STUDY
Herbal medicine is the oldest form of health care
known to mankind. The use of medicinal plant in the treatment of diseases has
been in practice since ancient time in different parts of the world especially
in Africa. Plants have always been the most vital source of drugs mainly
because most plants are autotrophs, and are able to synthesize a large variety
of basic biochemical and organic substances such as carbohydrates, protein,
terpenes, steroids, alkaloid and glycosides (N’guessanetal.,2009)
The plant kingdom provides a tremendous reservoir of
various chemical substances with potential therapeutic properties. Generally,
plants which produce constituents having medical values are designated as
medicinal plants (Lawrence et al., 2008).
In addition, all plants that taste bitter are used as medicine (Barrett, 2009).
Diabetes mellitus is characterize by insufficient
blood levels of the hormone insulin. If the blood concentration of insulin is
too low, muscle and liver cells do not absorb glucose from the blood which in
turn leads to increase levels of blood glucose (hyperglycemia), impaired
metabolism of fats and proteins, ketosis and possible diabetic coma. (willam, et.al 2009)During the past 12 years, the world
health organization has been collecting information on the prevalence of
diabetes mellitus in adult communities worldwide. Within the age range of 30-64
years, diabetes was found to be absent or rare in some traditional communities
in Melanesia, East Africa and South America. In communities of Europeanorigin,
the prevalence of diabetes were in the range of 3-10% but migrant indian,
Chinese and Hispanic American groups were at higher risk (15-20%). (Adetokunbo,
et.al.,2003)
A 2008 study completed in U.S. found the number of
America women entering pregnancy with pre-exisiting diabetes is increasing. In
fact, the rate of diabetes in expectant mothers has more than doubled in the
past six years. (Lawrence, et.al.,2008).
This is particularly problematic as diabetes raises the risk of complications
during pregnancy, as well as increasing the potential for the children of
diabetic mothers to become diabetic in the future
1.2
STATEMENT OF THE PROBLEM
Malnutrition is define as the lack of sufficient
nutrients, which are essential for the body’s normal functioning. Over time it
affects the bodily organs and results in mild to severe medical problems. One
of the malnutrition facts is that the number of hungry people is more in the
developing countries. If a pregnant woman is malnourished, it is understandable
that the baby in the mother’s womb is not receiving enough nutrient.
Pregnant women who have been through malnutrition,
deliver babies with low birth weight. Such children are prone to retarded
growth, less coordination, poor vision, learning difficulty, and many other
diseases. Anemia is one of the malnutrition dises that affects several pregnant
women worldwide.
1.3
AIM OF THE STUDY
To investigate the effect of high sucrose fed pregnant
rats in their offsprings and know their pancreatic effect. And also the effect of Buccholozia Coriacea
1.4
OBJECTIVES OF THE STUDY
Induce
diabetes by administering sucrose
Administering
plants for lowering blood sugar level
Measure
the blood and leptin level
================================================================
Item Type: Project Material | Attribute: 42 pages | Chapters: 1-5
Format: MS Word | Price: N3,000 | Delivery: Within 30Mins.
================================================================
No comments:
Post a Comment